Drug interactions
Danazol + Solifenacin
Severity: Moderate
Danazol and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak-to-moderate CYP3A4 inhibitor and may increase solifenacin exposure. This could raise the risk of anticholinergic effects and QT prolongation at higher exposures.
What this interaction means in plain words
Danazol and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 by danazol decreases solifenacin clearance.
What to do
Monitor for anticholinergic adverse effects and consider limiting solifenacin to 5 mg daily.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Frequently asked questions
Can I take Danazol with Solifenacin?
MediHelp rates the interaction as moderate. Danazol and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol is a weak-to-moderate CYP3A4 inhibitor and may increase solifenacin exposure. This could raise the risk of anticholinergic effects and QT prolongation at higher exposures.
How serious is the interaction between Danazol and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and consider limiting solifenacin to 5 mg daily.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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