Drug interactions
Danazol + Tacrolimus
Severity: Major
Danazol and Tacrolimus: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol inhibits CYP3A4 and has been reported to raise tacrolimus concentrations. This may lead to nephrotoxicity, neurotoxicity and other tacrolimus adverse effects.
What this interaction means in plain words
Danazol and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of CYP3A4-mediated tacrolimus metabolism by danazol.
What to do
Prefer an alternative to danazol. If it is necessary, reduce the tacrolimus dose and check trough levels and renal function frequently.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Danazol with Tacrolimus?
MediHelp rates the interaction as major. Danazol and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Danazol inhibits CYP3A4 and has been reported to raise tacrolimus concentrations. This may lead to nephrotoxicity, neurotoxicity and other tacrolimus adverse effects.
How serious is the interaction between Danazol and Tacrolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative to danazol. If it is necessary, reduce the tacrolimus dose and check trough levels and renal function frequently.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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