Drug interactions
Dapagliflozin + Glibenclamide
Severity: Moderate
Dapagliflozin and Glibenclamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dapagliflozin lowers glucose without stimulating insulin release, but combined with glyburide it increases the likelihood of hypoglycemia. The prolonged action of glyburide makes any episodes potentially long-lasting.
What this interaction means in plain words
Dapagliflozin and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin belongs to Endocrine; Glibenclamide belongs to Endocrine.
Why it happens
Additive pharmacodynamic glucose lowering from SGLT2-mediated urinary glucose excretion and sulfonylurea-driven insulin secretion.
What to do
Consider a lower glyburide dose when dapagliflozin is started. Monitor blood glucose closely and educate the patient about hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Other interactions of Dapagliflozin
- Chlorpropamide + Dapagliflozin Moderate
- Dapagliflozin + Gliclazide Moderate
- Dapagliflozin + Glimepiride Moderate
- Dapagliflozin + Glimepiride-pioglitazone Moderate
- Dapagliflozin + Glipizide Moderate
- Dapagliflozin + Glipizide-metformin Moderate
Frequently asked questions
Can I take Dapagliflozin with Glibenclamide?
MediHelp rates the interaction as moderate. Dapagliflozin and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dapagliflozin lowers glucose without stimulating insulin release, but combined with glyburide it increases the likelihood of hypoglycemia. The prolonged action of glyburide makes any episodes potentially long-lasting.
How serious is the interaction between Dapagliflozin and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lower glyburide dose when dapagliflozin is started. Monitor blood glucose closely and educate the patient about hypoglycemia.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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