Drug interactions
Dapagliflozin + Insulin aspart protamine / insulin aspart
Severity: Moderate
Dapagliflozin and Insulin aspart protamine / insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dapagliflozin added to insulin increases glucose lowering and the risk of hypoglycemia. Insulin doses often need to be reduced.
What this interaction means in plain words
Dapagliflozin and Insulin aspart protamine / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic glucose lowering: SGLT2 inhibition promotes urinary glucose loss while insulin lowers glucose directly.
What to do
Consider lowering the insulin dose when starting dapagliflozin and monitor blood glucose. Also watch for ketoacidosis, particularly if insulin is cut substantially.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin
- Chlorpropamide + Dapagliflozin Moderate
- Dapagliflozin + Gliclazide Moderate
- Dapagliflozin + Glimepiride Moderate
- Dapagliflozin + Glimepiride-pioglitazone Moderate
- Dapagliflozin + Glipizide Moderate
- Dapagliflozin + Glipizide-metformin Moderate
Frequently asked questions
Can I take Dapagliflozin with Insulin aspart protamine / insulin aspart?
MediHelp rates the interaction as moderate. Dapagliflozin and Insulin aspart protamine / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dapagliflozin added to insulin increases glucose lowering and the risk of hypoglycemia. Insulin doses often need to be reduced.
How serious is the interaction between Dapagliflozin and Insulin aspart protamine / insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the insulin dose when starting dapagliflozin and monitor blood glucose. Also watch for ketoacidosis, particularly if insulin is cut substantially.
What other medicines interact with Dapagliflozin?
MediHelp also lists interactions of Dapagliflozin with, for example, Chlorpropamide, Gliclazide, Glimepiride. The full list is on the Dapagliflozin page.
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