Drug interactions
Dapagliflozin + Insulin degludec / insulin aspart
Severity: Moderate
Dapagliflozin and Insulin degludec / insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dapagliflozin with insulin increases hypoglycemia risk through additive glucose lowering. Insulin dose reduction may be required.
What this interaction means in plain words
Dapagliflozin and Insulin degludec / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic glucose lowering from SGLT2-mediated glycosuria plus exogenous insulin.
What to do
Consider reducing the insulin dose at initiation and monitor glucose. Monitor for ketoacidosis if insulin is lowered significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin
- Chlorpropamide + Dapagliflozin Moderate
- Dapagliflozin + Gliclazide Moderate
- Dapagliflozin + Glimepiride Moderate
- Dapagliflozin + Glimepiride-pioglitazone Moderate
- Dapagliflozin + Glipizide Moderate
- Dapagliflozin + Glipizide-metformin Moderate
Frequently asked questions
Can I take Dapagliflozin with Insulin degludec / insulin aspart?
MediHelp rates the interaction as moderate. Dapagliflozin and Insulin degludec / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dapagliflozin with insulin increases hypoglycemia risk through additive glucose lowering. Insulin dose reduction may be required.
How serious is the interaction between Dapagliflozin and Insulin degludec / insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the insulin dose at initiation and monitor glucose. Monitor for ketoacidosis if insulin is lowered significantly.
What other medicines interact with Dapagliflozin?
MediHelp also lists interactions of Dapagliflozin with, for example, Chlorpropamide, Gliclazide, Glimepiride. The full list is on the Dapagliflozin page.
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