Drug interactions
Dapagliflozin + Insulin detemir
Severity: Moderate
Dapagliflozin and Insulin detemir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dapagliflozin added to insulin increases glucose lowering and hypoglycemia risk. Insulin dose reduction may be needed, but excessive reduction increases ketoacidosis risk.
What this interaction means in plain words
Dapagliflozin and Insulin detemir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin belongs to Endocrine; Insulin detemir belongs to Endocrine.
Why it happens
Additive glucose lowering from SGLT2-mediated urinary glucose excretion and exogenous insulin.
What to do
Consider a lower insulin dose when starting dapagliflozin and monitor glucose. Monitor for ketoacidosis symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin detemir
Other interactions of Dapagliflozin
- Chlorpropamide + Dapagliflozin Moderate
- Dapagliflozin + Gliclazide Moderate
- Dapagliflozin + Glimepiride Moderate
- Dapagliflozin + Glimepiride-pioglitazone Moderate
- Dapagliflozin + Glipizide Moderate
- Dapagliflozin + Glipizide-metformin Moderate
Frequently asked questions
Can I take Dapagliflozin with Insulin detemir?
MediHelp rates the interaction as moderate. Dapagliflozin and Insulin detemir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dapagliflozin added to insulin increases glucose lowering and hypoglycemia risk. Insulin dose reduction may be needed, but excessive reduction increases ketoacidosis risk.
How serious is the interaction between Dapagliflozin and Insulin detemir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lower insulin dose when starting dapagliflozin and monitor glucose. Monitor for ketoacidosis symptoms.
What other medicines interact with Insulin detemir?
MediHelp also lists interactions of Insulin detemir with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin detemir page.
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