Drug interactions
Dapagliflozin + Insulin isophane human / insulin regular human
Severity: Moderate
Dapagliflozin and Insulin isophane human / insulin regular human: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dapagliflozin with premixed human insulin raises hypoglycemia risk through additive effect. Insulin doses may need to be reduced.
What this interaction means in plain words
Dapagliflozin and Insulin isophane human / insulin regular human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic glucose lowering from SGLT2-mediated glycosuria plus exogenous insulin.
What to do
Consider a lower insulin dose when starting dapagliflozin and monitor glucose. Monitor for ketoacidosis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin
- Chlorpropamide + Dapagliflozin Moderate
- Dapagliflozin + Gliclazide Moderate
- Dapagliflozin + Glimepiride Moderate
- Dapagliflozin + Glimepiride-pioglitazone Moderate
- Dapagliflozin + Glipizide Moderate
- Dapagliflozin + Glipizide-metformin Moderate
Frequently asked questions
Can I take Dapagliflozin with Insulin isophane human / insulin regular human?
MediHelp rates the interaction as moderate. Dapagliflozin and Insulin isophane human / insulin regular human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dapagliflozin with premixed human insulin raises hypoglycemia risk through additive effect. Insulin doses may need to be reduced.
How serious is the interaction between Dapagliflozin and Insulin isophane human / insulin regular human?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lower insulin dose when starting dapagliflozin and monitor glucose. Monitor for ketoacidosis.
What other medicines interact with Dapagliflozin?
MediHelp also lists interactions of Dapagliflozin with, for example, Chlorpropamide, Gliclazide, Glimepiride. The full list is on the Dapagliflozin page.
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