Drug interactions
Dapagliflozin + Insulin lispro protamine / insulin lispro
Severity: Moderate
Dapagliflozin and Insulin lispro protamine / insulin lispro: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dapagliflozin plus premixed lispro insulin increases glucose-lowering and hypoglycemia risk. Insulin dose reduction may be needed.
What this interaction means in plain words
Dapagliflozin and Insulin lispro protamine / insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic glucose lowering from SGLT2-mediated glycosuria plus exogenous insulin.
What to do
Consider lowering the insulin dose at dapagliflozin initiation and monitor glucose. Monitor for ketoacidosis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dapagliflozin and Insulin lispro protamine / insulin lispro, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Dapagliflozin
- Chlorpropamide + Dapagliflozin Moderate
- Dapagliflozin + Gliclazide Moderate
- Dapagliflozin + Glimepiride Moderate
- Dapagliflozin + Glimepiride-pioglitazone Moderate
- Dapagliflozin + Glipizide Moderate
- Dapagliflozin + Glipizide-metformin Moderate
Frequently asked questions
Can I take Dapagliflozin with Insulin lispro protamine / insulin lispro?
MediHelp rates the interaction as moderate. Dapagliflozin and Insulin lispro protamine / insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dapagliflozin plus premixed lispro insulin increases glucose-lowering and hypoglycemia risk. Insulin dose reduction may be needed.
How serious is the interaction between Dapagliflozin and Insulin lispro protamine / insulin lispro?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the insulin dose at dapagliflozin initiation and monitor glucose. Monitor for ketoacidosis.
What other medicines interact with Dapagliflozin?
MediHelp also lists interactions of Dapagliflozin with, for example, Chlorpropamide, Gliclazide, Glimepiride. The full list is on the Dapagliflozin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
