Drug interactions
Dapagliflozin + Insulin lispro
Severity: Moderate
Dapagliflozin and Insulin lispro: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dapagliflozin lowers glucose by promoting urinary glucose excretion, so combined use with insulin raises hypoglycemia risk. Volume depletion and ketoacidosis are additional concerns in insulin-treated patients, particularly if insulin is reduced too much.
What this interaction means in plain words
Dapagliflozin and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin belongs to Endocrine; Insulin lispro belongs to Endocrine.
Why it happens
Additive glucose lowering from exogenous insulin and SGLT2 inhibition causing glucosuria.
What to do
Consider a lower insulin dose when starting dapagliflozin and monitor blood glucose. Avoid excessive insulin reduction and watch for ketoacidosis symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin lispro
Other interactions of Dapagliflozin
- Chlorpropamide + Dapagliflozin Moderate
- Dapagliflozin + Gliclazide Moderate
- Dapagliflozin + Glimepiride Moderate
- Dapagliflozin + Glimepiride-pioglitazone Moderate
- Dapagliflozin + Glipizide Moderate
- Dapagliflozin + Glipizide-metformin Moderate
Frequently asked questions
Can I take Dapagliflozin with Insulin lispro?
MediHelp rates the interaction as moderate. Dapagliflozin and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dapagliflozin lowers glucose by promoting urinary glucose excretion, so combined use with insulin raises hypoglycemia risk. Volume depletion and ketoacidosis are additional concerns in insulin-treated patients, particularly if insulin is reduced too much.
How serious is the interaction between Dapagliflozin and Insulin lispro?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lower insulin dose when starting dapagliflozin and monitor blood glucose. Avoid excessive insulin reduction and watch for ketoacidosis symptoms.
What other medicines interact with Insulin lispro?
MediHelp also lists interactions of Insulin lispro with, for example, Alogliptin-pioglitazone, Ethanol, Metreleptin. The full list is on the Insulin lispro page.
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