Drug interactions
Dapagliflozin + Insulin neutral human-insulin isophane protamine human
Severity: Moderate
Dapagliflozin and Insulin neutral human-insulin isophane protamine human: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dapagliflozin added to insulin increases the risk of hypoglycemia. Insulin dose reductions that are too aggressive may also contribute to euglycemic ketoacidosis.
What this interaction means in plain words
Dapagliflozin and Insulin neutral human-insulin isophane protamine human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin belongs to Endocrine; Insulin neutral human-insulin isophane protamine human belongs to Endocrine.
Why it happens
Additive glucose lowering from insulin and SGLT2-mediated urinary glucose loss.
What to do
Consider lowering the insulin dose when starting dapagliflozin and monitor glucose. Check ketones if the patient is unwell, vomiting or has reduced intake.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin neutral human-insulin isophane protamine human
- Ethanol + Insulin neutral human-insulin isophane protamine human Major
- Insulin neutral human-insulin isophane protamine human + Pentamidine Major
- Insulin neutral human-insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin neutral human-insulin isophane protamine human Moderate
- Albiglutide + Insulin neutral human-insulin isophane protamine human Moderate
- Alogliptin + Insulin neutral human-insulin isophane protamine human Moderate
Other interactions of Dapagliflozin
- Chlorpropamide + Dapagliflozin Moderate
- Dapagliflozin + Gliclazide Moderate
- Dapagliflozin + Glimepiride Moderate
- Dapagliflozin + Glimepiride-pioglitazone Moderate
- Dapagliflozin + Glipizide Moderate
- Dapagliflozin + Glipizide-metformin Moderate
Frequently asked questions
Can I take Dapagliflozin with Insulin neutral human-insulin isophane protamine human?
MediHelp rates the interaction as moderate. Dapagliflozin and Insulin neutral human-insulin isophane protamine human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dapagliflozin added to insulin increases the risk of hypoglycemia. Insulin dose reductions that are too aggressive may also contribute to euglycemic ketoacidosis.
How serious is the interaction between Dapagliflozin and Insulin neutral human-insulin isophane protamine human?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the insulin dose when starting dapagliflozin and monitor glucose. Check ketones if the patient is unwell, vomiting or has reduced intake.
What other medicines interact with Insulin neutral human-insulin isophane protamine human?
MediHelp also lists interactions of Insulin neutral human-insulin isophane protamine human with, for example, Ethanol, Pentamidine, Rosiglitazone. The full list is on the Insulin neutral human-insulin isophane protamine human page.
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