Drug interactions
Dapagliflozin + Lithium
Severity: Moderate
Dapagliflozin and Lithium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dapagliflozin may alter serum lithium concentrations, and lower levels have been described that could reduce mood-stabilizing effect. Volume depletion could in other cases raise levels, so the direction of change is unpredictable.
What this interaction means in plain words
Dapagliflozin and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin belongs to Endocrine; Lithium belongs to Central Nervous System.
Why it happens
SGLT2 inhibition alters renal sodium and volume handling, which may change renal lithium clearance; the mechanism is not firmly established.
What to do
Check serum lithium before starting dapagliflozin and again shortly after initiation or dose changes. Adjust lithium dosing based on levels and mood symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dapagliflozin and Lithium, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Other interactions of Dapagliflozin
- Chlorpropamide + Dapagliflozin Moderate
- Dapagliflozin + Gliclazide Moderate
- Dapagliflozin + Glimepiride Moderate
- Dapagliflozin + Glimepiride-pioglitazone Moderate
- Dapagliflozin + Glipizide Moderate
- Dapagliflozin + Glipizide-metformin Moderate
Frequently asked questions
Can I take Dapagliflozin with Lithium?
MediHelp rates the interaction as moderate. Dapagliflozin and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dapagliflozin may alter serum lithium concentrations, and lower levels have been described that could reduce mood-stabilizing effect. Volume depletion could in other cases raise levels, so the direction of change is unpredictable.
How serious is the interaction between Dapagliflozin and Lithium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum lithium before starting dapagliflozin and again shortly after initiation or dose changes. Adjust lithium dosing based on levels and mood symptoms.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
