Drug interactions
Dapagliflozin-metformin + Deflazacort
Severity: Moderate
Dapagliflozin-metformin and Deflazacort: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deflazacort is a glucocorticoid that can raise blood glucose and reduce the effect of antidiabetic drugs. Glycemic control may worsen, particularly during higher-dose or prolonged courses.
What this interaction means in plain words
Dapagliflozin-metformin and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Deflazacort belongs to Miscellaneous.
Why it happens
Glucocorticoids increase hepatic gluconeogenesis and induce peripheral insulin resistance, opposing the glucose-lowering effect.
What to do
Monitor blood glucose more often during corticosteroid therapy and adjust antidiabetic doses; reassess when the steroid is reduced or stopped to avoid hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Dapagliflozin-metformin with Deflazacort?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deflazacort is a glucocorticoid that can raise blood glucose and reduce the effect of antidiabetic drugs. Glycemic control may worsen, particularly during higher-dose or prolonged courses.
How serious is the interaction between Dapagliflozin-metformin and Deflazacort?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often during corticosteroid therapy and adjust antidiabetic doses; reassess when the steroid is reduced or stopped to avoid hypoglycemia.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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