Drug interactions
Dapagliflozin-metformin + Drospirenone
Severity: Minor
Dapagliflozin-metformin and Drospirenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone-containing contraceptives can slightly impair glucose tolerance, which may offset the effect of antidiabetic agents. Drospirenone also has antimineralocorticoid activity and may raise potassium, relevant in patients with reduced renal function.
What this interaction means in plain words
Dapagliflozin-metformin and Drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapagliflozin-metformin belongs to Endocrine; Drospirenone belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism via mild hormonal effects on insulin sensitivity.
What to do
Monitor glucose control after starting drospirenone, and check potassium and renal function if renal impairment is present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapagliflozin-metformin
Other interactions of Drospirenone
Frequently asked questions
Can I take Dapagliflozin-metformin with Drospirenone?
MediHelp rates the interaction as minor. Dapagliflozin-metformin and Drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone-containing contraceptives can slightly impair glucose tolerance, which may offset the effect of antidiabetic agents. Drospirenone also has antimineralocorticoid activity and may raise potassium, relevant in patients with reduced renal function.
How serious is the interaction between Dapagliflozin-metformin and Drospirenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose control after starting drospirenone, and check potassium and renal function if renal impairment is present.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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