Drug interactions
Dapagliflozin-metformin + Fosinopril
Severity: Moderate
Dapagliflozin-metformin and Fosinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and occasionally enhance glucose lowering. They may also reduce renal function in volume-depleted patients, which, together with dapagliflozin's diuretic effect, raises concern for acute kidney injury and metformin accumulation.
What this interaction means in plain words
Dapagliflozin-metformin and Fosinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Fosinopril belongs to Cardiovascular.
Why it happens
ACE inhibition may increase insulin sensitivity, and combined hemodynamic effects with SGLT2 inhibition may reduce renal function and metformin clearance.
What to do
Monitor renal function, volume status and blood glucose, especially at initiation; hold metformin if acute kidney injury or dehydration develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Fosinopril
- Aliskiren + Fosinopril Contraindicated
- Fosinopril + Protein a column Contraindicated
- Fosinopril + Sacubitril / valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Fosinopril Major
- Amiloride + Fosinopril Major
Frequently asked questions
Can I take Dapagliflozin-metformin with Fosinopril?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Fosinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and occasionally enhance glucose lowering. They may also reduce renal function in volume-depleted patients, which, together with dapagliflozin's diuretic effect, raises concern for acute kidney injury and metformin accumulation.
How serious is the interaction between Dapagliflozin-metformin and Fosinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, volume status and blood glucose, especially at initiation; hold metformin if acute kidney injury or dehydration develops.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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