Drug interactions
Dapagliflozin-metformin + Givinostat
Severity: Minor
Dapagliflozin-metformin and Givinostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat is a weak inhibitor of the renal transporters that clear metformin, which could slightly raise metformin exposure. The clinical impact is expected to be small.
What this interaction means in plain words
Dapagliflozin-metformin and Givinostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapagliflozin-metformin belongs to Endocrine; Givinostat belongs to Miscellaneous.
Why it happens
Weak inhibition of renal cationic transporters reduces metformin tubular secretion.
What to do
Monitor for metformin adverse effects and renal function. Reduce the metformin dose if tolerability worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapagliflozin-metformin
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Dapagliflozin-metformin with Givinostat?
MediHelp rates the interaction as minor. Dapagliflozin-metformin and Givinostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Givinostat is a weak inhibitor of the renal transporters that clear metformin, which could slightly raise metformin exposure. The clinical impact is expected to be small.
How serious is the interaction between Dapagliflozin-metformin and Givinostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for metformin adverse effects and renal function. Reduce the metformin dose if tolerability worsens.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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