Drug interactions
Dapagliflozin-metformin + Imipramine
Severity: Minor
Dapagliflozin-metformin and Imipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants have been reported to alter glucose regulation, and hypoglycemia or glycemic variability may occur in patients on antidiabetic agents. The effect is inconsistent and usually modest.
What this interaction means in plain words
Dapagliflozin-metformin and Imipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapagliflozin-metformin belongs to Endocrine; Imipramine belongs to Central Nervous System.
Why it happens
The mechanism is not well established; tricyclics may affect insulin sensitivity and glucose handling, with effects on appetite and weight.
What to do
No routine change is needed; monitor blood glucose when starting or stopping the antidepressant.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapagliflozin-metformin
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Dapagliflozin-metformin with Imipramine?
MediHelp rates the interaction as minor. Dapagliflozin-metformin and Imipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants have been reported to alter glucose regulation, and hypoglycemia or glycemic variability may occur in patients on antidiabetic agents. The effect is inconsistent and usually modest.
How serious is the interaction between Dapagliflozin-metformin and Imipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor blood glucose when starting or stopping the antidepressant.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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