Drug interactions
Dapagliflozin-metformin + Isocarboxazid
Severity: Moderate
Dapagliflozin-metformin and Isocarboxazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors can lower blood glucose and enhance the effect of antidiabetic drugs, with hypoglycemia reported mainly with insulin and sulfonylureas. The risk with metformin and dapagliflozin is lower but not absent.
What this interaction means in plain words
Dapagliflozin-metformin and Isocarboxazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Isocarboxazid belongs to Central Nervous System.
Why it happens
MAO inhibition may enhance insulin secretion and sensitivity, adding to glucose lowering; the exact mechanism is not fully established.
What to do
Monitor blood glucose when isocarboxazid is started or stopped and reduce antidiabetic doses if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Dapagliflozin-metformin with Isocarboxazid?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Isocarboxazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors can lower blood glucose and enhance the effect of antidiabetic drugs, with hypoglycemia reported mainly with insulin and sulfonylureas. The risk with metformin and dapagliflozin is lower but not absent.
How serious is the interaction between Dapagliflozin-metformin and Isocarboxazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when isocarboxazid is started or stopped and reduce antidiabetic doses if hypoglycemia occurs.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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