Drug interactions
Dapagliflozin-metformin + Ketotifen
Severity: Minor
Dapagliflozin-metformin and Ketotifen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketotifen has been linked with reversible thrombocytopenia in oral use alongside metformin, an old labeled warning. Ophthalmic ketotifen has minimal systemic absorption, so a clinically meaningful interaction is unlikely.
What this interaction means in plain words
Dapagliflozin-metformin and Ketotifen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapagliflozin-metformin belongs to Endocrine; Ketotifen belongs to Respiratory.
Why it happens
No established mechanism; a possible additive hematologic effect is theoretical.
What to do
No action is needed for ophthalmic use; if oral ketotifen is used, check a blood count if bruising or bleeding occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapagliflozin-metformin
Other interactions of Ketotifen
- Ketotifen + Phenobarbital Moderate
- Ketotifen + Pholcodine Moderate
- Ketotifen + Primidone Moderate
- Ketotifen + Protriptyline Moderate
- Ketotifen + Quazepam Moderate
- Ketotifen + Rotigotine Moderate
Frequently asked questions
Can I take Dapagliflozin-metformin with Ketotifen?
MediHelp rates the interaction as minor. Dapagliflozin-metformin and Ketotifen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ketotifen has been linked with reversible thrombocytopenia in oral use alongside metformin, an old labeled warning. Ophthalmic ketotifen has minimal systemic absorption, so a clinically meaningful interaction is unlikely.
How serious is the interaction between Dapagliflozin-metformin and Ketotifen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed for ophthalmic use; if oral ketotifen is used, check a blood count if bruising or bleeding occurs.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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