Drug interactions
Dapagliflozin-metformin + Lisinopril
Severity: Moderate
Dapagliflozin-metformin and Lisinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and occasionally lower blood glucose, so hypoglycemia may be more likely in patients on glucose-lowering therapy. Combined use with dapagliflozin also adds to volume depletion and changes in renal function, which can raise metformin exposure and the risk of lactic acidosis.
What this interaction means in plain words
Dapagliflozin-metformin and Lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Lisinopril belongs to Cardiovascular.
Why it happens
Additive glucose lowering through improved insulin sensitivity, plus additive volume depletion and hemodynamic effects on renal function that may reduce metformin clearance.
What to do
Monitor blood glucose, blood pressure, volume status, serum creatinine and eGFR, especially at initiation and dose changes. Hold or reduce therapy if renal function declines or volume depletion develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Frequently asked questions
Can I take Dapagliflozin-metformin with Lisinopril?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and occasionally lower blood glucose, so hypoglycemia may be more likely in patients on glucose-lowering therapy. Combined use with dapagliflozin also adds to volume depletion and changes in renal function, which can raise metformin exposure and the risk of lactic acidosis.
How serious is the interaction between Dapagliflozin-metformin and Lisinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, blood pressure, volume status, serum creatinine and eGFR, especially at initiation and dose changes. Hold or reduce therapy if renal function declines or volume depletion develops.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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