Drug interactions
Dapagliflozin-metformin + Nateglinide
Severity: Moderate
Dapagliflozin-metformin and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining dapagliflozin-metformin with nateglinide, an insulin secretagogue, increases the risk of hypoglycemia.
What this interaction means in plain words
Dapagliflozin-metformin and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Nateglinide belongs to Endocrine.
Why it happens
Additive glucose-lowering through insulin secretion and complementary antihyperglycemic mechanisms.
What to do
Consider lowering the nateglinide dose when starting dapagliflozin-metformin and monitor blood glucose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Dapagliflozin-metformin with Nateglinide?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining dapagliflozin-metformin with nateglinide, an insulin secretagogue, increases the risk of hypoglycemia.
How serious is the interaction between Dapagliflozin-metformin and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the nateglinide dose when starting dapagliflozin-metformin and monitor blood glucose.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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