Drug interactions
Dapagliflozin-metformin + Nelfinavir
Severity: Moderate
Dapagliflozin-metformin and Nelfinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir can cause insulin resistance and hyperglycemia, which may reduce the effectiveness of metformin and dapagliflozin. Glucose control can worsen during therapy.
What this interaction means in plain words
Dapagliflozin-metformin and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Nelfinavir belongs to Anti Virals.
Why it happens
Protease inhibitors induce insulin resistance and impair glucose uptake.
What to do
Monitor glucose and HbA1c after starting nelfinavir and intensify antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Dapagliflozin-metformin with Nelfinavir?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nelfinavir can cause insulin resistance and hyperglycemia, which may reduce the effectiveness of metformin and dapagliflozin. Glucose control can worsen during therapy.
How serious is the interaction between Dapagliflozin-metformin and Nelfinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c after starting nelfinavir and intensify antidiabetic therapy as needed.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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