Drug interactions
Dapagliflozin-metformin + Nilotinib
Severity: Moderate
Dapagliflozin-metformin and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib is associated with hyperglycemia in some patients, which may reduce the effect of antidiabetic treatment. Glucose elevations are generally manageable with monitoring.
What this interaction means in plain words
Dapagliflozin-metformin and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Nilotinib belongs to Oncology.
Why it happens
Pharmacodynamic antagonism; nilotinib-related hyperglycemia, the mechanism of which is not fully established.
What to do
Monitor glucose before and during nilotinib therapy and intensify antidiabetic treatment if hyperglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dapagliflozin-metformin and Nilotinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Dapagliflozin-metformin
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Dapagliflozin-metformin with Nilotinib?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib is associated with hyperglycemia in some patients, which may reduce the effect of antidiabetic treatment. Glucose elevations are generally manageable with monitoring.
How serious is the interaction between Dapagliflozin-metformin and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose before and during nilotinib therapy and intensify antidiabetic treatment if hyperglycemia develops.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
