Drug interactions
Dapagliflozin-metformin + Ofloxacin
Severity: Moderate
Dapagliflozin-metformin and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause both hypoglycemia and hyperglycemia in patients taking antidiabetic drugs, particularly older adults and those with renal impairment. Ofloxacin may cause significant glucose disturbances during treatment.
What this interaction means in plain words
Dapagliflozin-metformin and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Ofloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolones affect pancreatic beta-cell potassium channels, altering insulin secretion and causing dysglycemia.
What to do
Monitor blood glucose during the antibiotic course and counsel the patient on hypoglycemia symptoms. Stop the quinolone and treat if significant dysglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Dapagliflozin-metformin with Ofloxacin?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can cause both hypoglycemia and hyperglycemia in patients taking antidiabetic drugs, particularly older adults and those with renal impairment. Ofloxacin may cause significant glucose disturbances during treatment.
How serious is the interaction between Dapagliflozin-metformin and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during the antibiotic course and counsel the patient on hypoglycemia symptoms. Stop the quinolone and treat if significant dysglycemia occurs.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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