Drug interactions
Dapagliflozin-metformin + Paroxetine
Severity: Minor
Dapagliflozin-metformin and Paroxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SSRIs such as paroxetine may enhance glucose lowering and occasionally cause hypoglycemia in patients on antidiabetic drugs. Metformin and dapagliflozin have low hypoglycemia risk by themselves, so the effect is usually modest.
What this interaction means in plain words
Dapagliflozin-metformin and Paroxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapagliflozin-metformin belongs to Endocrine; Paroxetine belongs to Central Nervous System.
Why it happens
Possible additive glucose lowering through improved insulin sensitivity; the mechanism is not firmly established.
What to do
Monitor blood glucose when starting or stopping paroxetine and adjust antidiabetic therapy only if glucose changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapagliflozin-metformin
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Dapagliflozin-metformin with Paroxetine?
MediHelp rates the interaction as minor. Dapagliflozin-metformin and Paroxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. SSRIs such as paroxetine may enhance glucose lowering and occasionally cause hypoglycemia in patients on antidiabetic drugs. Metformin and dapagliflozin have low hypoglycemia risk by themselves, so the effect is usually modest.
How serious is the interaction between Dapagliflozin-metformin and Paroxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping paroxetine and adjust antidiabetic therapy only if glucose changes.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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