Drug interactions
Dapagliflozin-metformin + Phenelzine
Severity: Moderate
Dapagliflozin-metformin and Phenelzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors such as phenelzine can enhance insulin sensitivity and lower blood glucose, causing hypoglycemia in patients taking antidiabetic drugs. The risk is greater with insulin or sulfonylureas than with metformin or dapagliflozin alone.
What this interaction means in plain words
Dapagliflozin-metformin and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Phenelzine belongs to Central Nervous System.
Why it happens
Additive glucose lowering through MAO inhibitor effects on insulin sensitivity and insulin secretion.
What to do
Monitor blood glucose when starting or stopping phenelzine and reduce antidiabetic doses if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Dapagliflozin-metformin with Phenelzine?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors such as phenelzine can enhance insulin sensitivity and lower blood glucose, causing hypoglycemia in patients taking antidiabetic drugs. The risk is greater with insulin or sulfonylureas than with metformin or dapagliflozin alone.
How serious is the interaction between Dapagliflozin-metformin and Phenelzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping phenelzine and reduce antidiabetic doses if hypoglycemia occurs.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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