Drug interactions
Dapagliflozin-metformin + Somapacitan
Severity: Moderate
Dapagliflozin-metformin and Somapacitan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone reduces insulin sensitivity and can raise blood glucose. This may weaken the glucose-lowering effect of dapagliflozin and metformin.
What this interaction means in plain words
Dapagliflozin-metformin and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Somapacitan belongs to Endocrine.
Why it happens
Growth hormone induces insulin resistance and opposes the glucose-lowering actions of antidiabetic drugs.
What to do
Monitor blood glucose and HbA1c after starting or changing the dose of somapacitan. Adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Somapacitan
- Alogliptin-metformin + Somapacitan Moderate
- Alogliptin-pioglitazone + Somapacitan Moderate
- Alogliptin + Somapacitan Moderate
- Bazedoxifene-conjugated estrogens + Somapacitan Moderate
- Canagliflozin-metformin + Somapacitan Moderate
- Chlorpropamide + Somapacitan Moderate
Frequently asked questions
Can I take Dapagliflozin-metformin with Somapacitan?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone reduces insulin sensitivity and can raise blood glucose. This may weaken the glucose-lowering effect of dapagliflozin and metformin.
How serious is the interaction between Dapagliflozin-metformin and Somapacitan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or changing the dose of somapacitan. Adjust antidiabetic therapy as needed.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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