Drug interactions
Daprodustat + Irbesartan
Severity: Moderate
Daprodustat and Irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Daprodustat is cleared mainly by CYP2C8, and irbesartan is reported to have weak to moderate inhibitory activity against it. Higher daprodustat exposure could increase the risk of its adverse effects, including excessive hemoglobin rise.
What this interaction means in plain words
Daprodustat and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daprodustat belongs to Endocrine; Irbesartan belongs to Cardiovascular.
Why it happens
Possible inhibition of CYP2C8-mediated metabolism of daprodustat by irbesartan.
What to do
Monitor hemoglobin and adjust the daprodustat dose when irbesartan is started or stopped. Follow labeling for dose reduction with CYP2C8 inhibitors if clinically relevant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Other interactions of Daprodustat
- Daprodustat + Gemfibrozil Contraindicated
- Abiraterone + Daprodustat Moderate
- Alogliptin-pioglitazone + Daprodustat Moderate
- Carbamazepine + Daprodustat Moderate
- Clopidogrel + Daprodustat Moderate
- Daprodustat + Deferasirox Moderate
Frequently asked questions
Can I take Daprodustat with Irbesartan?
MediHelp rates the interaction as moderate. Daprodustat and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Daprodustat is cleared mainly by CYP2C8, and irbesartan is reported to have weak to moderate inhibitory activity against it. Higher daprodustat exposure could increase the risk of its adverse effects, including excessive hemoglobin rise.
How serious is the interaction between Daprodustat and Irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin and adjust the daprodustat dose when irbesartan is started or stopped. Follow labeling for dose reduction with CYP2C8 inhibitors if clinically relevant.
What other medicines interact with Irbesartan?
MediHelp also lists interactions of Irbesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Irbesartan page.
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