Drug interactions
Daprodustat + Lapatinib
Severity: Moderate
Daprodustat and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib may increase daprodustat exposure through CYP2C8 inhibition. Higher exposure may cause excessive hemoglobin rise and thromboembolic or cardiovascular events.
What this interaction means in plain words
Daprodustat and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daprodustat belongs to Endocrine; Lapatinib belongs to Oncology.
Why it happens
Inhibition of CYP2C8-mediated daprodustat metabolism by lapatinib.
What to do
Reduce the daprodustat starting dose per labeling for CYP2C8 inhibitors. Monitor hemoglobin and adjust dose when lapatinib is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Daprodustat
- Daprodustat + Gemfibrozil Contraindicated
- Abiraterone + Daprodustat Moderate
- Alogliptin-pioglitazone + Daprodustat Moderate
- Carbamazepine + Daprodustat Moderate
- Clopidogrel + Daprodustat Moderate
- Daprodustat + Deferasirox Moderate
Frequently asked questions
Can I take Daprodustat with Lapatinib?
MediHelp rates the interaction as moderate. Daprodustat and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib may increase daprodustat exposure through CYP2C8 inhibition. Higher exposure may cause excessive hemoglobin rise and thromboembolic or cardiovascular events.
How serious is the interaction between Daprodustat and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the daprodustat starting dose per labeling for CYP2C8 inhibitors. Monitor hemoglobin and adjust dose when lapatinib is started or stopped.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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