Drug interactions
Daprodustat + Mifepristone
Severity: Moderate
Daprodustat and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone may inhibit CYP2C8, which is the main metabolic route of daprodustat, and so could raise daprodustat concentrations. Excessive exposure may cause a too-rapid hemoglobin rise and increase thrombotic and cardiovascular risk.
What this interaction means in plain words
Daprodustat and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daprodustat belongs to Endocrine; Mifepristone belongs to Endocrine.
Why it happens
Inhibition of CYP2C8-mediated daprodustat metabolism.
What to do
Consider halving the daprodustat starting dose when a moderate CYP2C8 inhibitor is used. Monitor hemoglobin and adjust the dose when mifepristone is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Daprodustat
- Daprodustat + Gemfibrozil Contraindicated
- Abiraterone + Daprodustat Moderate
- Alogliptin-pioglitazone + Daprodustat Moderate
- Carbamazepine + Daprodustat Moderate
- Clopidogrel + Daprodustat Moderate
- Daprodustat + Deferasirox Moderate
Frequently asked questions
Can I take Daprodustat with Mifepristone?
MediHelp rates the interaction as moderate. Daprodustat and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone may inhibit CYP2C8, which is the main metabolic route of daprodustat, and so could raise daprodustat concentrations. Excessive exposure may cause a too-rapid hemoglobin rise and increase thrombotic and cardiovascular risk.
How serious is the interaction between Daprodustat and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider halving the daprodustat starting dose when a moderate CYP2C8 inhibitor is used. Monitor hemoglobin and adjust the dose when mifepristone is started or stopped.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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