Drug interactions
Daprodustat + Rifampicin
Severity: Moderate
Daprodustat and Rifampicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampicin induces CYP2C8 and can lower daprodustat exposure, potentially reducing its effect on hemoglobin.
What this interaction means in plain words
Daprodustat and Rifampicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daprodustat belongs to Endocrine; Rifampicin belongs to Anti Bacterial.
Why it happens
Induction of CYP2C8-mediated metabolism of daprodustat.
What to do
Monitor hemoglobin and titrate the daprodustat dose according to response when rifampicin is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Daprodustat
- Daprodustat + Gemfibrozil Contraindicated
- Abiraterone + Daprodustat Moderate
- Alogliptin-pioglitazone + Daprodustat Moderate
- Carbamazepine + Daprodustat Moderate
- Clopidogrel + Daprodustat Moderate
- Daprodustat + Deferasirox Moderate
Other interactions of Rifampicin
- Cabotegravir + Rifampicin Contraindicated
- Delamanid + Rifampicin Contraindicated
- Doravirine + Rifampicin Contraindicated
- Ensitrelvir + Rifampicin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
Frequently asked questions
Can I take Daprodustat with Rifampicin?
MediHelp rates the interaction as moderate. Daprodustat and Rifampicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampicin induces CYP2C8 and can lower daprodustat exposure, potentially reducing its effect on hemoglobin.
How serious is the interaction between Daprodustat and Rifampicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin and titrate the daprodustat dose according to response when rifampicin is started or stopped.
What other medicines interact with Daprodustat?
MediHelp also lists interactions of Daprodustat with, for example, Gemfibrozil, Abiraterone, Alogliptin-pioglitazone. The full list is on the Daprodustat page.
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