Drug interactions
Dapsone + Disulfiram
Severity: Minor
Dapsone and Disulfiram: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disulfiram inhibits CYP2E1, which has at most a minor role in dapsone metabolism. Any rise in dapsone levels is expected to be small and the significance is unknown.
What this interaction means in plain words
Dapsone and Disulfiram have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Disulfiram inhibits CYP2E1, potentially reducing a minor dapsone clearance pathway.
What to do
No routine adjustment is needed. Be aware that both drugs can cause neurotoxicity, and monitor for neuropathy symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Frequently asked questions
Can I take Dapsone with Disulfiram?
MediHelp rates the interaction as minor. Dapsone and Disulfiram have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Disulfiram inhibits CYP2E1, which has at most a minor role in dapsone metabolism. Any rise in dapsone levels is expected to be small and the significance is unknown.
How serious is the interaction between Dapsone and Disulfiram?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Be aware that both drugs can cause neurotoxicity, and monitor for neuropathy symptoms.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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