Drug interactions
Dapsone + Elvitegravir / cobicistat / emtricitabine / tenofovir df
Severity: Moderate
Dapsone and Elvitegravir / cobicistat / emtricitabine / tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dapsone is metabolized partly by CYP3A4 and CYP2C9, and cobicistat is a strong CYP3A4 inhibitor that may raise dapsone exposure. Dapsone toxicity includes dose-related hemolysis and methemoglobinemia. There is no labeled contraindication, and the dapsone-related effects are manageable with monitoring.
What this interaction means in plain words
Dapsone and Elvitegravir / cobicistat / emtricitabine / tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat inhibits CYP3A4, reducing dapsone clearance, while elvitegravir's CYP2C9 induction may partially offset this.
What to do
Monitor hemoglobin, methemoglobin and symptoms of hemolysis, and consider a lower dapsone dose if toxicity develops. Check G6PD status before use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Frequently asked questions
Can I take Dapsone with Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates the interaction as moderate. Dapsone and Elvitegravir / cobicistat / emtricitabine / tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dapsone is metabolized partly by CYP3A4 and CYP2C9, and cobicistat is a strong CYP3A4 inhibitor that may raise dapsone exposure. Dapsone toxicity includes dose-related hemolysis and methemoglobinemia. There is no labeled contraindication, and the dapsone-related effects are manageable with monitoring.
How serious is the interaction between Dapsone and Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin, methemoglobin and symptoms of hemolysis, and consider a lower dapsone dose if toxicity develops. Check G6PD status before use.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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