Drug interactions
Dapsone + Erythromycin base
Severity: Minor
Dapsone and Erythromycin base: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits CYP3A4, which contributes to dapsone metabolism, so dapsone exposure may rise modestly. This could increase dose-related hematologic toxicity such as hemolysis and methemoglobinemia.
What this interaction means in plain words
Dapsone and Erythromycin base have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Erythromycin inhibits CYP3A4-mediated metabolism of dapsone.
What to do
No routine dose change is needed; monitor blood counts and watch for cyanosis or anemia, especially in G6PD deficiency.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Frequently asked questions
Can I take Dapsone with Erythromycin base?
MediHelp rates the interaction as minor. Dapsone and Erythromycin base have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erythromycin inhibits CYP3A4, which contributes to dapsone metabolism, so dapsone exposure may rise modestly. This could increase dose-related hematologic toxicity such as hemolysis and methemoglobinemia.
How serious is the interaction between Dapsone and Erythromycin base?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor blood counts and watch for cyanosis or anemia, especially in G6PD deficiency.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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