Drug interactions
Dapsone + Fexinidazole
Severity: Moderate
Dapsone and Fexinidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dapsone is partly metabolized by CYP3A4, and fexinidazole may inhibit this enzyme. Higher dapsone exposure could increase hemolysis and methemoglobinemia. Both drugs can also affect blood parameters.
What this interaction means in plain words
Dapsone and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fexinidazole inhibition of CYP3A4 may reduce dapsone N-hydroxylation clearance.
What to do
Monitor hemoglobin and methemoglobin levels, and watch for cyanosis or dyspnea. Consider a dapsone alternative during fexinidazole treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Frequently asked questions
Can I take Dapsone with Fexinidazole?
MediHelp rates the interaction as moderate. Dapsone and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dapsone is partly metabolized by CYP3A4, and fexinidazole may inhibit this enzyme. Higher dapsone exposure could increase hemolysis and methemoglobinemia. Both drugs can also affect blood parameters.
How serious is the interaction between Dapsone and Fexinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin and methemoglobin levels, and watch for cyanosis or dyspnea. Consider a dapsone alternative during fexinidazole treatment.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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