Drug interactions
Dapsone + Ibuprofen / famotidine
Severity: Minor
Dapsone and Ibuprofen / famotidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dapsone absorption has been proposed to depend on gastric acidity, but clinically significant reductions with acid suppressants are not well established. Any effect is likely small.
What this interaction means in plain words
Dapsone and Ibuprofen / famotidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Raised gastric pH from famotidine may slightly reduce dapsone dissolution and absorption.
What to do
No routine action needed. Monitor clinical response if dapsone efficacy seems reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Frequently asked questions
Can I take Dapsone with Ibuprofen / famotidine?
MediHelp rates the interaction as minor. Dapsone and Ibuprofen / famotidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dapsone absorption has been proposed to depend on gastric acidity, but clinically significant reductions with acid suppressants are not well established. Any effect is likely small.
How serious is the interaction between Dapsone and Ibuprofen / famotidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action needed. Monitor clinical response if dapsone efficacy seems reduced.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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