Drug interactions
Dapsone + Indinavir
Severity: Minor
Dapsone and Indinavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4 and may raise dapsone levels. The effect is likely modest but could increase dose-related hematologic toxicity.
What this interaction means in plain words
Dapsone and Indinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Indinavir inhibits CYP3A4, reducing dapsone metabolism.
What to do
Monitor for hemolysis and methemoglobinemia. Reduce the dapsone dose if adverse effects appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Frequently asked questions
Can I take Dapsone with Indinavir?
MediHelp rates the interaction as minor. Dapsone and Indinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Indinavir inhibits CYP3A4 and may raise dapsone levels. The effect is likely modest but could increase dose-related hematologic toxicity.
How serious is the interaction between Dapsone and Indinavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for hemolysis and methemoglobinemia. Reduce the dapsone dose if adverse effects appear.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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