Drug interactions
Dapsone + Lumacaftor / ivacaftor
Severity: Moderate
Dapsone and Lumacaftor / ivacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor is a strong CYP3A inducer and may lower dapsone levels, while ivacaftor may inhibit some pathways. The net effect on dapsone is uncertain, and reduced efficacy is the main concern.
What this interaction means in plain words
Dapsone and Lumacaftor / ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lumacaftor induces CYP3A4 and other enzymes, potentially lowering dapsone exposure; ivacaftor effects are minor and the net effect is uncertain.
What to do
Monitor for loss of dapsone efficacy, such as prophylaxis failure or lack of clinical response, and adjust therapy accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Frequently asked questions
Can I take Dapsone with Lumacaftor / ivacaftor?
MediHelp rates the interaction as moderate. Dapsone and Lumacaftor / ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumacaftor is a strong CYP3A inducer and may lower dapsone levels, while ivacaftor may inhibit some pathways. The net effect on dapsone is uncertain, and reduced efficacy is the main concern.
How serious is the interaction between Dapsone and Lumacaftor / ivacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of dapsone efficacy, such as prophylaxis failure or lack of clinical response, and adjust therapy accordingly.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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