Drug interactions
Dapsone + Lumefantrine
Severity: Minor
Dapsone and Lumefantrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine is not a well-established CYP3A4 inducer, so any effect on dapsone is theoretical. A clinically meaningful reduction in dapsone levels is unlikely.
What this interaction means in plain words
Dapsone and Lumefantrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
A weak effect on CYP3A4 has been suggested, but the mechanism is not established.
What to do
No action is needed beyond awareness. Monitor clinical response to dapsone.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Frequently asked questions
Can I take Dapsone with Lumefantrine?
MediHelp rates the interaction as minor. Dapsone and Lumefantrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lumefantrine is not a well-established CYP3A4 inducer, so any effect on dapsone is theoretical. A clinically meaningful reduction in dapsone levels is unlikely.
How serious is the interaction between Dapsone and Lumefantrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed beyond awareness. Monitor clinical response to dapsone.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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