Drug interactions
Dapsone + Methotrexate
Severity: Moderate
Dapsone and Methotrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause hematologic toxicity, and dapsone may cause hemolysis, methemoglobinemia and agranulocytosis. Combined use may increase the risk of cytopenias.
What this interaction means in plain words
Dapsone and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapsone belongs to Anti Bacterial; Methotrexate belongs to Oncology.
Why it happens
Additive bone marrow and hematologic toxicity, including the antifolate effect of methotrexate.
What to do
Monitor complete blood count regularly, including reticulocytes where hemolysis is suspected. Reduce dose or stop one agent if significant cytopenia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Frequently asked questions
Can I take Dapsone with Methotrexate?
MediHelp rates the interaction as moderate. Dapsone and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause hematologic toxicity, and dapsone may cause hemolysis, methemoglobinemia and agranulocytosis. Combined use may increase the risk of cytopenias.
How serious is the interaction between Dapsone and Methotrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood count regularly, including reticulocytes where hemolysis is suspected. Reduce dose or stop one agent if significant cytopenia occurs.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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