Drug interactions
Dapsone + Metronidazole
Severity: Minor
Dapsone and Metronidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metronidazole has been proposed to raise dapsone exposure through effects on oxidative metabolism, but the clinical significance is unclear. Both drugs can cause peripheral neuropathy, so combined use may add to neurotoxic risk with prolonged treatment.
What this interaction means in plain words
Dapsone and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapsone belongs to Anti Bacterial; Metronidazole belongs to Anti Parasitic.
Why it happens
Possible weak inhibition of CYP-mediated dapsone metabolism, plus additive neurotoxic potential.
What to do
No dose change is routinely required; monitor for neuropathy and hemolysis if therapy is prolonged.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dapsone and Metronidazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Frequently asked questions
Can I take Dapsone with Metronidazole?
MediHelp rates the interaction as minor. Dapsone and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metronidazole has been proposed to raise dapsone exposure through effects on oxidative metabolism, but the clinical significance is unclear. Both drugs can cause peripheral neuropathy, so combined use may add to neurotoxic risk with prolonged treatment.
How serious is the interaction between Dapsone and Metronidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely required; monitor for neuropathy and hemolysis if therapy is prolonged.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
