Drug interactions
Dapsone + Sodium citrate / citric acid
Severity: Minor
Dapsone and Sodium citrate / citric acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Citrate buffer solutions raise gastric pH transiently and might slightly reduce dapsone absorption, but no meaningful clinical effect is established.
What this interaction means in plain words
Dapsone and Sodium citrate / citric acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Transient increase in gastric pH may slightly reduce dapsone dissolution.
What to do
No routine action needed. Separate doses by a couple of hours if desired.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Frequently asked questions
Can I take Dapsone with Sodium citrate / citric acid?
MediHelp rates the interaction as minor. Dapsone and Sodium citrate / citric acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Citrate buffer solutions raise gastric pH transiently and might slightly reduce dapsone absorption, but no meaningful clinical effect is established.
How serious is the interaction between Dapsone and Sodium citrate / citric acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action needed. Separate doses by a couple of hours if desired.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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