Drug interactions
Dapsone + Typhoid vaccine live
Severity: Moderate
Dapsone and Typhoid vaccine live: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral live typhoid vaccine (Ty21a) relies on replication of attenuated bacteria in the gut. Antibacterials may suppress the strain and reduce immunogenicity. Dapsone's antibacterial effect on Salmonella is not well characterized, so the interaction is largely theoretical.
What this interaction means in plain words
Dapsone and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity may reduce replication of the live attenuated vaccine strain, lowering the immune response.
What to do
Complete the live typhoid vaccine series at least a few days before starting dapsone when possible, or use the inactivated injectable vaccine instead.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Frequently asked questions
Can I take Dapsone with Typhoid vaccine live?
MediHelp rates the interaction as moderate. Dapsone and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral live typhoid vaccine (Ty21a) relies on replication of attenuated bacteria in the gut. Antibacterials may suppress the strain and reduce immunogenicity. Dapsone's antibacterial effect on Salmonella is not well characterized, so the interaction is largely theoretical.
How serious is the interaction between Dapsone and Typhoid vaccine live?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete the live typhoid vaccine series at least a few days before starting dapsone when possible, or use the inactivated injectable vaccine instead.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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