Drug interactions
Daratumumab + Deferiprone
Severity: Major
Daratumumab and Deferiprone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Daratumumab can cause neutropenia and thrombocytopenia, and deferiprone can cause agranulocytosis. Together the risk of severe neutropenia and infection may be increased.
What this interaction means in plain words
Daratumumab and Deferiprone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Daratumumab belongs to Oncology; Deferiprone belongs to Miscellaneous.
Why it happens
Additive hematologic toxicity affecting neutrophils.
What to do
Avoid if possible; if both are required, monitor absolute neutrophil count more frequently and interrupt deferiprone for neutropenia or fever.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Deferiprone
- Clozapine + Deferiprone Contraindicated
- Abemaciclib + Deferiprone Major
- Acalabrutinib + Deferiprone Major
- Ado-trastuzumab emtansine + Deferiprone Major
- Ado-trastuzumab + Deferiprone Major
- Aldesleukin + Deferiprone Major
Other interactions of Daratumumab
- Daratumumab + Siponimod Moderate
Frequently asked questions
Can I take Daratumumab with Deferiprone?
MediHelp rates the interaction as major. Daratumumab and Deferiprone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Daratumumab can cause neutropenia and thrombocytopenia, and deferiprone can cause agranulocytosis. Together the risk of severe neutropenia and infection may be increased.
How serious is the interaction between Daratumumab and Deferiprone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if both are required, monitor absolute neutrophil count more frequently and interrupt deferiprone for neutropenia or fever.
What other medicines interact with Deferiprone?
MediHelp also lists interactions of Deferiprone with, for example, Clozapine, Abemaciclib, Acalabrutinib. The full list is on the Deferiprone page.
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