Drug interactions
Daratumumab + Siponimod
Severity: Moderate
Daratumumab and Siponimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Daratumumab depletes CD38-expressing cells including some lymphocytes and is associated with infections, and siponimod reduces lymphocyte counts. The combination may add to infection risk.
What this interaction means in plain words
Daratumumab and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daratumumab belongs to Oncology; Siponimod belongs to Central Nervous System.
Why it happens
Additive immune suppression from CD38-targeted cell depletion and siponimod-induced lymphocyte sequestration.
What to do
Monitor lymphocyte and neutrophil counts and for signs of infection. Consider holding siponimod if serious infection develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Siponimod
- Cladribine + Siponimod Contraindicated
- Fingolimod + Siponimod Contraindicated
- Fluconazole + Siponimod Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Siponimod + Thioridazine Contraindicated
Other interactions of Daratumumab
Frequently asked questions
Can I take Daratumumab with Siponimod?
MediHelp rates the interaction as moderate. Daratumumab and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Daratumumab depletes CD38-expressing cells including some lymphocytes and is associated with infections, and siponimod reduces lymphocyte counts. The combination may add to infection risk.
How serious is the interaction between Daratumumab and Siponimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lymphocyte and neutrophil counts and for signs of infection. Consider holding siponimod if serious infection develops.
What other medicines interact with Siponimod?
MediHelp also lists interactions of Siponimod with, for example, Cladribine, Fingolimod, Fluconazole. The full list is on the Siponimod page.
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