Drug interactions
Daridorexant + Esketamine
Severity: Moderate
Daridorexant and Esketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Daridorexant is an orexin antagonist causing somnolence and next-day impairment. With esketamine, additive CNS effects may worsen psychomotor performance and daytime function.
What this interaction means in plain words
Daridorexant and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daridorexant belongs to Central Nervous System; Esketamine belongs to Central Nervous System.
Why it happens
Additive CNS depression through pharmacodynamic effects.
What to do
Monitor for next-day sedation and impairment and consider lowering the daridorexant dose if impairment occurs. Counsel patients on driving and hazardous activities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Daridorexant
Frequently asked questions
Can I take Daridorexant with Esketamine?
MediHelp rates the interaction as moderate. Daridorexant and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Daridorexant is an orexin antagonist causing somnolence and next-day impairment. With esketamine, additive CNS effects may worsen psychomotor performance and daytime function.
How serious is the interaction between Daridorexant and Esketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for next-day sedation and impairment and consider lowering the daridorexant dose if impairment occurs. Counsel patients on driving and hazardous activities.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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