Drug interactions
Daridorexant + Fentanyl
Severity: Moderate
Daridorexant and Fentanyl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so combining them increases sedation and impairs psychomotor performance and next-day alertness. Respiratory depression is possible with higher opioid doses.
What this interaction means in plain words
Daridorexant and Fentanyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daridorexant belongs to Central Nervous System; Fentanyl belongs to Musculoskeletal.
Why it happens
Additive CNS depression from opioid agonism and orexin receptor antagonism.
What to do
Use the lowest effective dose of daridorexant and counsel patients about daytime impairment and driving. Monitor for excessive sedation and respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Daridorexant
Frequently asked questions
Can I take Daridorexant with Fentanyl?
MediHelp rates the interaction as moderate. Daridorexant and Fentanyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so combining them increases sedation and impairs psychomotor performance and next-day alertness. Respiratory depression is possible with higher opioid doses.
How serious is the interaction between Daridorexant and Fentanyl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective dose of daridorexant and counsel patients about daytime impairment and driving. Monitor for excessive sedation and respiratory depression.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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