Drug interactions
Daridorexant + Isoniazid
Severity: Moderate
Daridorexant and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid inhibits CYP3A4, the main pathway for daridorexant clearance, which may increase exposure and next-day somnolence. The effect is likely moderate rather than strong.
What this interaction means in plain words
Daridorexant and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daridorexant belongs to Central Nervous System; Isoniazid belongs to Anti Bacterial.
Why it happens
CYP3A4 inhibition by isoniazid reduces daridorexant metabolism.
What to do
Limit daridorexant to 25 mg nightly and monitor for daytime drowsiness and impaired driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Daridorexant
Frequently asked questions
Can I take Daridorexant with Isoniazid?
MediHelp rates the interaction as moderate. Daridorexant and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoniazid inhibits CYP3A4, the main pathway for daridorexant clearance, which may increase exposure and next-day somnolence. The effect is likely moderate rather than strong.
How serious is the interaction between Daridorexant and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit daridorexant to 25 mg nightly and monitor for daytime drowsiness and impaired driving.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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