Drug interactions
Daridorexant + Lithium
Severity: Moderate
Daridorexant and Lithium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs may cause sedation and psychomotor impairment. Together they may increase drowsiness, including next-day impairment after a bedtime dose of daridorexant.
What this interaction means in plain words
Daridorexant and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daridorexant belongs to Central Nervous System; Lithium belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Use the lowest effective daridorexant dose and monitor for daytime somnolence. Advise patients to avoid driving if impaired.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Other interactions of Daridorexant
Frequently asked questions
Can I take Daridorexant with Lithium?
MediHelp rates the interaction as moderate. Daridorexant and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs may cause sedation and psychomotor impairment. Together they may increase drowsiness, including next-day impairment after a bedtime dose of daridorexant.
How serious is the interaction between Daridorexant and Lithium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective daridorexant dose and monitor for daytime somnolence. Advise patients to avoid driving if impaired.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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