Drug interactions
Daridorexant + Metronidazole
Severity: Moderate
Daridorexant and Metronidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metronidazole may increase daridorexant exposure through CYP3A4 inhibition, potentially causing greater next-day somnolence and impaired alertness.
What this interaction means in plain words
Daridorexant and Metronidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daridorexant belongs to Central Nervous System; Metronidazole belongs to Anti Parasitic.
Why it happens
CYP3A4 inhibition by metronidazole reduces daridorexant clearance.
What to do
Limit daridorexant to 25 mg nightly during metronidazole use. Counsel patients about daytime drowsiness and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Daridorexant
Frequently asked questions
Can I take Daridorexant with Metronidazole?
MediHelp rates the interaction as moderate. Daridorexant and Metronidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metronidazole may increase daridorexant exposure through CYP3A4 inhibition, potentially causing greater next-day somnolence and impaired alertness.
How serious is the interaction between Daridorexant and Metronidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit daridorexant to 25 mg nightly during metronidazole use. Counsel patients about daytime drowsiness and driving.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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