Drug interactions
Daridorexant + Olanzapine
Severity: Moderate
Daridorexant and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system. Combined use can add to drowsiness and impair psychomotor performance and next-day alertness.
What this interaction means in plain words
Daridorexant and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daridorexant belongs to Central Nervous System; Olanzapine belongs to Central Nervous System.
Why it happens
Additive CNS depression from orexin receptor antagonism and olanzapine's sedating antihistaminic and antiserotonergic activity.
What to do
Use the lowest effective dose of daridorexant and advise patients to avoid driving or hazardous tasks until they know how they respond. Avoid alcohol and other sedatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Daridorexant
Frequently asked questions
Can I take Daridorexant with Olanzapine?
MediHelp rates the interaction as moderate. Daridorexant and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system. Combined use can add to drowsiness and impair psychomotor performance and next-day alertness.
How serious is the interaction between Daridorexant and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective dose of daridorexant and advise patients to avoid driving or hazardous tasks until they know how they respond. Avoid alcohol and other sedatives.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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